Your pharmacogenetics (PGx) test results help you identify what meds work best for you. Eliminate trial and error prescribing. PGx testing gives you and your physicians genetic insight into your body’s ability to process different drugs. This test provides empirical results to help you and your provider select the best medicine from the beginning to achieve the best heart health outcome.

For medicines you are currently or considering taking, screen for:

• Increased Drug Toxicity

Your body metabolizes the drug too rapidly, leading to potential adverse side effects of a standard dose.

• Reduced Drug Efficacy

Your body metabolizes the drug too slowly, leading to the medication not working as intended.

• Hypersensitivity Drug Risk

Your body’s genetic profile causes you to react severely to a typical drug dose.

We also analyze your genetic predisposition to having an increased risk for the following four cardiovascular diseases:

• Cardiovascular Genetic Disease Risk Assessment

• Hyperlipidemia: Certain genetic variants are associated with elevated lipoprotein levels that can lead to an increased risk of atherosclerosis and cardiovascular disease.
• Hyperlipoproteinemia Type III: The inability to break down fats (lipids) correctly.
• Hyperhomocysteinemia-Thrombosis: Increased risk of venous thromboembolism (clots in the veins).
• Thrombophilia: Abnormal blood clotting

Your result includes a free telehealth report explanation to help you get the most out of your test. View a Cardiac Medication Response (PGx Gene Test) sample report here.

4U Health’s Cardiac Medication Response Test informs you on the usefulness of 40+ medications mainly used to help improve cardiovascular health, including Angiotensin II Receptor Antagonists, Antianginal Agents, Antiarrhythmics, Anticoagulants, Antiplatelets, Beta Blockers, Diuretics, and Statins.

Discover how your body is likely to metabolize this extensive list of cardiac drugs and use your results to learn which medicines may cause a good therapeutic or bad adverse outcome. For more information on which drugs this test covers, view full list of medications here.

Our cardiac pharmacogenomics (PGx) test provides essential information on 13 genes which may affect metabolism and response to cardiovascular drugs across eight classes – Angiotensin II Receptor Antagonists, Antianginal Agents, Antiarrhythmics, Anticoagulants, Antiplatelets, Beta Blockers, Diuretics, and Statins. Clinicians can use the personalized information provided with this PGx test to help select the best cardiac medication and dose for an individual patient, limiting potential adverse drug reactions.

Drug Metabolism Genotyping
Also known as pharmacokinetics, this analysis predicts the body’s impact on a drug. Its purpose is to determine patient-specific genetic variants that may influence the function of drug-metabolizing enzymes. It shows whether a patient is an ultrarapid metabolizer, extensive metabolizer, intermediate metabolizer, or poor metabolizer of a medication. Understanding your metabolizer phenotype is important, as it indicates how much of a drug may be active in the body to produce either therapeutic or toxic effects.

Drug Response Genotyping
Also known as pharmacodynamics, this analysis describes a drug’s predictive impact on the body. It considers the likelihood of a drug producing the desired therapeutic effect by identifying patient-specific genetic variants involved in how medications work. This can indicate the likelihood of a good (therapeutic) or bad (adverse) drug response.

Clinicians prescribe medications to treat disease or alleviate symptoms. The last thing you might expect is that a prescribed medication may do more harm than good. An adverse drug reaction (ADR) refers to the unintended side effects of a prescribed medication. A drug-induced disease occurs when an ADR warrants a patient consulting a doctor or getting hospitalized.

ADRs and drug-induced diseases are a reality. FDA studies estimate that 7% of hospitalized patients have a severe adverse drug reaction.² Drugs are approved by the FDA for use only if their potential benefits far outweigh the risks involved. But it’s important to note not all people react similarly to a drug. A particular medicine may benefit some people while causing others potentially life-threatening unintended side effects.

A drug response test like this alerts patients and guides clinicians through the practice of personalized medicine. It allows prescribers to empirically select the best medications based on a patient’s unique genetic traits. This test may increase the likelihood of an optimal therapeutic outcome and limit the chances of an adverse drug reaction.

One of the transformative trends in medicine is personalized pharmacy therapy. With the advent of medication response PGx tests, physicians and pharmacists alike can individualize a patient’s drug therapy consistent with that patient’s unique genetic makeup.

Our Cardiac Medication Response (PGx Gene Test) provides personalized medication guidance on 40+ drugs across eight classes including Angiotensin II Receptor Antagonists, Antianginal Agents, Antiarrhythmics, Anticoagulants, Antiplatelets, Beta Blockers, Diuretics, and Statins.

This state-of-the-art genetic test includes at no additional charge result explanation by a healthcare professional to help you better understand your medication response report. We’ll give you the information necessary to have an informed discussion with your physicians and pharmacists to get the most out of your results.

This test provides an analysis of 13 genes to identify 40+ medications often used to help improve cardiovascular health for potential genetic induced adverse drug reactions.

Analyzes 13 Genes:
Apolipoprotein E, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5, Factor II, Factor V Leiden, ITGB3, LPA, MTHFR, SLCO1B1, and VKORC1.

See Full List of Genes and Alleles Tested

Multiple factors influence how a person reacts to a drug including:

• Genetics
• Age
• Allergies
• Medical History
• Weight and Body Size

The Cardiac Medication Response (PGx Gene Test) is not suitable for the following groups of people:

• Children under 2-years-old
• Specimens collected in New York State

If you’re experiencing a severe adverse drug reaction, such as difficulty breathing, vision problems, hives, fever, or vomiting, we recommend you speak with your healthcare provider right away.

Test now or within one year of purchase. This kit has a guaranteed expiration date of at least 12 months. That’s great news if you are buying now but want to test yourself in the future or gifting to a friend or family member for later use.

All 4U Health tests are eligible for gifting. In fact, they make great presents. The recipient who receives your gift will simply open the kit, register it, and follow the collection instructions. Within a few days of sending to the lab, your friend or family member will receive secure electronic HIPAA compliant results all thanks to your generosity.

4U Health tests meet national standards and are as accurate as services provided in a doctor’s office or hospital. We only work with the highest quality CLIA certified laboratories and health experts. All testing complies with state and federal regulations. And our clinicians provide medical oversight throughout the entire process.

Rest assured; HIPAA security standards protect your data every step of the way while determining your gene to drug responses. Keeping your confidential data secure is our number one priority. We only share your information when required to deliver our products and services or where we are legally obligated to do so. Your results are securely protected and available for review in your online portal; always secure but easily accessible only to you.

Many physicians don’t routinely order a medication response PGx Gene test. That’s because DNA tests like this often require pre-authorization from insurance carriers. If denied, patients with insurance coverage may face unexpected medical bills often in excess of a thousand dollars.

With 4U Health you pay a fair price upfront and receive no surprise medical bills. 4U Health is not enrolled in Medicare or any other private insurance network. This test is not eligible for Medicare or any other federal or state-funded insurance program reimbursement.

So you still have unanswered questions. No worries, we’d love to hear from you. Reach us by e-mail, phone or chat and we will do our best to provide answers so you can determine if this is the best test for you or your child.

• 866-610-1200
• help@4uhealth.com
• Chat Support 
   
• PO Box 100083
  Pittsburgh, PA 15233