Cardiac Drug Sensitivity (PGx Gene Test)
At-Home Genetic Test To Identify Cardiac Meds That Work Best for You
4U Health At-Home Cardiac Medication Response (PGx Gene Test)
$289.00
Description
DNA test to personalize your cardiovascular and statin medicines to your genetics
4U Health’s Cardiac Medication Response Test analyzes 13 specific genes in your body known to impact the usefulness of 40+ cardiovascular medications.
Finding the right medicines to treat heart and vascular problems can be a frustrating trial-and-error process that often includes unintended side effects. Get a personalized medicine report unique to your specific DNA to predict how you will respond to this extensive list of cardiovascular medications. Share your results with your prescribing physician(s) to help optimize current medications and the future selection of drugs most likely to provide optimal heart health.
- Assesses your body’s response to 40+ prescribed cardiac drugs
- Provides a genetic risk rating for 5 cardiac diseases
- Includes free telehealth result explanation
- Simple at-home DNA cheek swab
- Available for ages 2+
- Upgrade to test 224 medicines
Enjoy: 20% OFF | Get it for: $231.20
Use code at checkout: HEALTHY20
4U Health Cardiac Medication Response (PGx Gene Test)
You want to match with the right cardiovascular medicines based on your unique DNA
A medication response test can help reduce trial-and-error prescribing with personalized drugs and doses. Over 90% of the population has at least one actionable gene variant that may affect the usefulness of prescribed medications and cause side effects.1
Test to:
- Find which heart drugs may work more or less effectively for you
- Learn which heart drugs may give you more or fewer side effects
- Know in advance of being prescribed a heart medication if it’s likely the best option for you
Analyzes 13 of your genes that may affect the usefulness of 40+ cardiovascular medicines
We’ll analyze 13 of your genes for important genetic variations in your DNA that may affect your response to medicines used to treat abnormal heartbeats (atrial fibrillation & other arrhythmias), atherosclerosis (plaque in the arteries), blood clots, chest pain, heart attack, high blood pressure, high cholesterol, heart failure, stroke, and water retention.
Results show which drugs may require dose adjustments, be less likely to work, or have an increased risk of side effects. Your report classifies 40+ cardiac drugs into three categories:
- STANDARD PRECAUTIONS – Use as directed
- USE WITH CAUTION – Moderate gene-drug interaction
- CONSIDER ALTERNATIVES – Significant gene-drug interaction
This test might be right for you if:
- You want a report you can share now or in the future with any pharmacist or physician to help increase the likelihood you are prescribed the best cardiac medication option
- You are experiencing less than optimal results from currently prescribed heart medications
- You plan to take a new cardiovascular prescription
- You have a personal or family history of adverse drug reactions
- You want to learn your genetic risk assessment for 5 cardiac diseases
Easily collect a cheek swab from the comfort and privacy of your own home
Your DNA test kit includes everything required for your mouth swab sample. We provide detailed instructions and a prepaid shipping label to return your sample to the lab.
Parents, we’ve got you covered – test any child 2 years and older. Mouth swabs are easy and painless!

Our tests bring hospital-grade results to your home
Once we receive your test, we’ll send your physician-reviewed results usually within 2-5 days. 4U Health at-home test reports are both accurate and easy to read. Your test includes a free telehealth result explanation. Feel free to use your results to identify any potential gene to drug interactions for current or proposed prescriptions. Prior to stopping any medications, share your results with your doctor or pharmacist to guide a discussion if a change in your treatment plan is appropriate.
This Test
This Test
Cardiac Medication Response
(PGx Gene Test)
Our Cardiac Medication Response Test analyzes 13 specific genes in your body known to impact the usefulness of 40+ cardiovascular focused medicines. It’s an ideal test to check your body’s response to common heart medications to help select the proper drug and dose from the onset of your treatment.
- Assess the body’s response to 40+ prescribed cardiac drugs; provides a genetic risk rating for 5 cardiac diseases
Cardiac Medication Response (PGx Gene Test)
Our Cardiac Medication Response Test analyzes 13 specific genes in your body known to impact the usefulness of 40+ cardiovascular focused medicines. It’s an ideal test to check your body’s response to common heart medications to help select the proper drug and dose from the onset of your treatment.
- Assess the body’s response to 40+ prescribed cardiac drugs; provides a genetic risk rating for 5 cardiac diseases
$289.00
$289.00
Upgrade Test Option
Upgrade Test Option
Comprehensive Medication Response
(PGx Gene Test)
4U Health’s Comprehensive Medication Response Test analyzes 20 specific genes in your body known to impact the usefulness of 224 medications. Checks your body’s response to cardiac medicines + anti-cancer, diabetes, gastrointestinal, infectious disease, pain management, psychiatric, rheumatology, transplantation, and urology drugs.
- Assesses your body’s response to 224 prescribed drugs; provides a genetic risk rating for 9 cardiac and psychiatric diseases
Comprehensive Medication Response (PGx Gene Test)
4U Health’s Comprehensive Medication Response Test analyzes 20 specific genes in your body known to impact the usefulness of 224 medications. Checks your body’s response to cardiac medicines + anti-cancer, diabetes, gastrointestinal, infectious disease, pain management, psychiatric, rheumatology, transplantation, and urology drugs.
- Assesses your body’s response to 224 prescribed drugs; provides a genetic risk rating for 9 cardiac and psychiatric diseases
$349.00
$349.00
Digital Results
Usually within 2 to 5 days of your sample arriving at the lab, receive secure electronic results on your device of choice
Simple
Simple to understand results to identify potential harmful drug to gene interactions.
Individualized
Your individualized genetic report ranks 40+ cardiac medications to help guide current and future selection of drugs that increase the likelihood of the best medical outcome.
Useful Results
Share your hospital-grade results with your doctors and pharmacist to eliminate trial and error prescribing – ensure the best selection of cardiovascular medicines to efficiently treat your symptoms while reducing risks of negative side effects.
How It Works

Step 1
Order Your Test
Order online with express delivery. In 1 to 2 days your DNA collection kit will arrive in plain packaging, ensuring a confidential testing experience.

Step 2
Collect Your Sample
Your kit contains everything you need to test from home. Simply collect your cheek swab sample using the at-home testing kit and instructions. Then return free of charge to the lab with the provided prepaid shipping label.

Step 3
Fast, Accurate Results
Typically you will receive electronic results within 2-5 days after receipt by the lab. Have complete trust in your lab report’s accuracy, as all 4U Health testing kits provide hospital-grade certified results.

Step 4
Get Physician Support
We’ve got you covered! A licensed physician orders your test and reviews your results. Your test includes free telehealth result explanation to help you maximize our laboratory services.
Frequently Asked Questions
What’s included in the at-home Medication Response (PGx Gene Test)?
You’ll receive everything you need in order to self-collect your test specimen!
- Pre-paid shipping both ways
- Easy to follow instructions
- An at-home DNA collection kit (via an easy cheek swab)
- Return protective envelope to mail sample to the lab for testing
- Electronic passcode protected results available from your phone or computer
- Free telehealth result explanation
- Printable report to share with your doctor
- Help along the way if you need it
What will my test results show me?
Your pharmacogenetics (PGx) test results help you identify what meds work best for you. Eliminate trial and error prescribing. PGx testing gives you and your physicians genetic insight into your body’s ability to process different drugs. This test provides empirical results to help you and your provider select the best medicine from the beginning to achieve the best heart health outcome.
For medicines you are currently or considering taking, screen for:
- Increased Drug Toxicity
Your body metabolizes the drug too rapidly, leading to potential adverse side effects of a standard dose.
- Reduced Drug Efficacy
Your body metabolizes the drug too slowly, leading to the medication not working as intended.
- Hypersensitivity Drug Risk
Your body’s genetic profile causes you to react severely to a typical drug dose.
We also analyze your genetic predisposition to having an increased risk for the following four cardiovascular diseases:
- Cardiovascular Genetic Disease Risk Assessment
- Hyperlipidemia: Certain genetic variants are associated with elevated lipoprotein levels that can lead to an increased risk of atherosclerosis and cardiovascular disease.
- Hyperlipoproteinemia Type III: The inability to break down fats (lipids) correctly.
- Hyperhomocysteinemia-Thrombosis: Increased risk of venous thromboembolism (clots in the veins).
- Thrombophilia: Abnormal blood clotting
Your result includes a free telehealth report explanation to help you get the most out of your test. View a Cardiac Medication Response (PGx Gene Test) sample report here.
What drugs does the Cardiac Medication Response Test cover?
4U Health’s Cardiac Medication Response Test informs you on the usefulness of 40+ medications mainly used to help improve cardiovascular health, including Angiotensin II Receptor Antagonists, Antianginal Agents, Antiarrhythmics, Anticoagulants, Antiplatelets, Beta Blockers, Diuretics, and Statins.
Discover how your body is likely to metabolize this extensive list of cardiac drugs and use your results to learn which medicines may cause a good therapeutic or bad adverse outcome. For more information on which drugs this test covers, view full list of medications here.
What's a medication response pharmacogenomics (PGx) gene test?
Our cardiac pharmacogenomics (PGx) test provides essential information on 13 genes which may affect metabolism and response to cardiovascular drugs across eight classes – Angiotensin II Receptor Antagonists, Antianginal Agents, Antiarrhythmics, Anticoagulants, Antiplatelets, Beta Blockers, Diuretics, and Statins. Clinicians can use the personalized information provided with this PGx test to help select the best cardiac medication and dose for an individual patient, limiting potential adverse drug reactions.
Drug Metabolism Genotyping
Also known as pharmacokinetics, this analysis predicts the body’s impact on a drug. Its purpose is to determine patient-specific genetic variants that may influence the function of drug-metabolizing enzymes. It shows whether a patient is an ultrarapid metabolizer, extensive metabolizer, intermediate metabolizer, or poor metabolizer of a medication. Understanding your metabolizer phenotype is important, as it indicates how much of a drug may be active in the body to produce either therapeutic or toxic effects.
Drug Response Genotyping
Also known as pharmacodynamics, this analysis describes a drug’s predictive impact on the body. It considers the likelihood of a drug producing the desired therapeutic effect by identifying patient-specific genetic variants involved in how medications work. This can indicate the likelihood of a good (therapeutic) or bad (adverse) drug response.
What's a drug-induced disease?
Clinicians prescribe medications to treat disease or alleviate symptoms. The last thing you might expect is that a prescribed medication may do more harm than good. An adverse drug reaction (ADR) refers to the unintended side effects of a prescribed medication. A drug-induced disease occurs when an ADR warrants a patient consulting a doctor or getting hospitalized.
ADRs and drug-induced diseases are a reality. FDA studies estimate that 7% of hospitalized patients have a severe adverse drug reaction.2 Drugs are approved by the FDA for use only if their potential benefits far outweigh the risks involved. But it’s important to note not all people react similarly to a drug. A particular medicine may benefit some people while causing others potentially life-threatening unintended side effects.
A drug response test like this alerts patients and guides clinicians through the practice of personalized medicine. It allows prescribers to empirically select the best medications based on a patient’s unique genetic traits. This test may increase the likelihood of an optimal therapeutic outcome and limit the chances of an adverse drug reaction.
What's personalized pharmacy therapy?
One of the transformative trends in medicine is personalized pharmacy therapy. With the advent of medication response PGx tests, physicians and pharmacists alike can individualize a patient’s drug therapy consistent with that patient’s unique genetic makeup.
Our Cardiac Medication Response (PGx Gene Test) provides personalized medication guidance on 40+ drugs across eight classes including Angiotensin II Receptor Antagonists, Antianginal Agents, Antiarrhythmics, Anticoagulants, Antiplatelets, Beta Blockers, Diuretics, and Statins.
Does this test include result explanation?
This state-of-the-art genetic test includes at no additional charge result explanation by a healthcare professional to help you better understand your medication response report. We’ll give you the information necessary to have an informed discussion with your physicians and pharmacists to get the most out of your results.
What genes does the Cardiac Medication Response Test analyze?
This test provides an analysis of 13 genes to identify 40+ medications often used to help improve cardiovascular health for potential genetic induced adverse drug reactions.
Analyzes 13 Genes:
Apolipoprotein E, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5, Factor II, Factor V Leiden, ITGB3, LPA, MTHFR, SLCO1B1, and VKORC1.
What factors commonly influence the body's response to a medication?
Multiple factors influence how a person reacts to a drug including:
- Genetics
- Age
- Allergies
- Medical History
- Weight and Body Size
Who should not take this test?
The Cardiac Medication Response (PGx Gene Test) is not suitable for the following groups of people:
- Children under 2-years-old
- Specimens collected in New York State
If you’re experiencing a severe adverse drug reaction, such as difficulty breathing, vision problems, hives, fever, or vomiting, we recommend you speak with your healthcare provider right away.
Can I buy now and use this test later?
Test now or within one year of purchase. This kit has a guaranteed expiration date of at least 12 months. That’s great news if you are buying now but want to test yourself in the future or gifting to a friend or family member for later use.
Can I gift this test to a friend or family member?
All 4U Health tests are eligible for gifting. In fact, they make great presents. The recipient who receives your gift will simply open the kit, register it, and follow the collection instructions. Within a few days of sending to the lab, your friend or family member will receive secure electronic HIPAA compliant results all thanks to your generosity.
Where is my lab test performed?
4U Health tests meet national standards and are as accurate as services provided in a doctor’s office or hospital. We only work with the highest quality CLIA certified laboratories and health experts. All testing complies with state and federal regulations. And our clinicians provide medical oversight throughout the entire process.
How is my privacy protected?
Rest assured; HIPAA security standards protect your data every step of the way while determining your gene to drug responses. Keeping your confidential data secure is our number one priority. We only share your information when required to deliver our products and services or where we are legally obligated to do so. Your results are securely protected and available for review in your online portal; always secure but easily accessible only to you.
Will my Medication Response Test be covered by insurance?
Many physicians don’t routinely order a medication response PGx Gene test. That’s because DNA tests like this often require pre-authorization from insurance carriers. If denied, patients with insurance coverage may face unexpected medical bills often in excess of a thousand dollars.
With 4U Health you pay a fair price upfront and receive no surprise medical bills. 4U Health is not enrolled in Medicare or any other private insurance network. This test is not eligible for Medicare or any other federal or state-funded insurance program reimbursement.
Still have questions about the test?
So you still have unanswered questions. No worries, we’d love to hear from you. Reach us by e-mail, phone or chat and we will do our best to provide answers so you can determine if this is the best test for you or your child.
- 866-610-1200
- help@4uhealth.com
- Chat Support
- PO Box 100083
Pittsburgh, PA 15233